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Departamento de Medicina Cardiovascular, Cleveland Clinic, Cleveland, Ohio; Departamento de Medicina Interna, Cleveland Clinic, Cleveland, Ohio; Departamento de Ciências Quantitativas da Saúde, Cleveland Clinic, Cleveland, Ohio; Departamento de Cardiologia, Piedmont Heart Institute, Atlanta, Geórgia; Department of Cardiovascular Medicine, University of Michigan, Ann Arbor, Michigan; Division of Prevention and Population Science, National Heart, Lung, and Blood Institute, National Institute of Health, Bethesda, Maryland; Division of Cardiovascular Diseases, Scripps Clinic and The Scripps Research Institute, La Jolla, Califórnia.