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Department of Medicine, Institute of Health Policy Management and Evaluation, Department of Anesthesia, University of Toronto, Toronto, Ontário, Canadá; Li Ka Shing Knowledge Institute, St Michael’s Hospital, Toronto, Ontário, Canadá; Central Ontario Region, Canadian Blood Services, Toronto, Ontário, Canadá; Ottawa Hospital Research Institute, Ottawa, Ontário, Canadá; Institute for Clinical Evaluative Sciences, Toronto, Ontário, Canadá; Department of Medicine, University of Ottawa, Toronto, Ontário, Canadá; Baycrest Geriatric Health Care Centre, Toronto, Ontário, Canadá; Sunnybrook Health Sciences Centre, Toronto, Ontário, Canadá; Division of Cardiac Surgery, University of Ottawa Heart Institute, Ottawa, Ontário, Canadá.